改变大脑功能和结构在COVID-19感染前和后:一项纵向研究
1Department of Radiology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Stadium Road 453#, Xihu District, Hangzhou City, 310000, Zhejiang Province, China.
概括
COVID-19 感染会影响大脑功能,改变运动和感官系统. 神经成像显示大脑活动和结构的变化,可能增加对焦虑和情绪障碍的易感性.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- SARS-CoV-2 可以感染大脑,导致神经系统症状.
- 缺乏关于COVID-19对大脑功能影响的长度研究.
- 功能磁共振成像 (fMRI) 用于调查这些影响.
研究的目的:
- 使用fMRI调查COVID-19对大脑功能的纵向影响.
- 在感染后识别大脑活动,结构和连接性的变化.
主要方法:
- 21名参与者在COVID-19感染之前和之后接受了休息状态的fMRI扫描.
- 评估低频波动幅度的变化 (ALFF) 和区域同质性 (ReHo).
- 利用基于声素的形态测量 (VBM) 进行结构分析和功能连接 (FC) 分析.
主要成果:
- 在近中心叶和后中心环中增加ALFF;在前骨中减少ALFF.
- 在小脑虫中降低了ReHo,并在后中心回中降低了FC.
- 左丘脑灰质体积的减少; precuneus ALFF和焦虑评分之间的负相关性.
结论:
- 神经成像改变可能会先于临床症状,影响运动和感官系统.
- COVID-19 感染可能会增加对不适应反应和情绪障碍的易感性.
- fMRI可以检测与COVID-19相关的早期功能和结构性大脑变化.
更多相关视频
相关概念视频
01:26Longitudinal Studies
168
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
168
02:20Longitudinal Research
12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K