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Updated: Jul 9, 2025

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
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Published on: September 30, 2016

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从长椅到床边:KRAS向治疗的当前发展和新兴趋势

Yi Chen1,2, Qiu-Pei Liu1,3, Hua Xie4,5,6

  • 1Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Acta pharmacologica Sinica
|December 4, 2023
PubMed
概括

克拉斯突变通过将蛋白质锁定到活性状态来驱动癌症. 性KRASG12C抑制剂为特定癌症提供了突破性的治疗方法,目前正在进行的研究正在探索新的抑制剂和间接向策略.

关键词:
在KRAS突变中发生突变.这是一种KRASG12C抑制剂.这是一种泛KRAS抑制剂.这是一种SHP2全抑制剂.这是一种SOS1抑制剂.组合疗法治疗组合治疗.

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