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甲型流感感染:疾病严重程度的预测因素

L A Pereira¹, B A Lapinscki¹, J S Santos²

¹Graduate Program in Internal Medicine and Health Science, Federal University of Paraná, Curitiba, 82060-240, Brazil.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

|December 4, 2023

概括

流感A感染的严重程度是由神经肌肉和心血管疾病,H1N1亚型和病毒载量预测的. 一个新的预后得分准确地识别了需要重症监护的患者.

科学领域:

* 传染病传染病
* 流行病学流行病学
* 临床医学临床医学

背景情况:

* A型流感病毒 (IFA) 导致全球每年显著的发病率和死亡率.
*严重的急性呼吸道感染是一种常见的并发症,需要10-40%的住院患者进行密集治疗.
* 确定预后不佳的多因素预测因素对于有效的疾病管理策略至关重要.

研究的目的:

* 确定IFA感染患者疾病严重程度的预测因子.
* 开发一个预后得分来预测IFA患者的重症监护室 (ICU) 住院情况.

主要方法:

*对142名感染IFA的门诊患者和住院患者 (2010-2018年) 的回顾性横截面研究.
*对病毒亚型,血凝素突变,病毒载量,IL-28B单核酸多态 (SNP) 和临床风险因素的评估.
*多变量分析以确定与ICU入院相关的风险因素.

主要成果:

*严重的IFA感染的关键风险因素包括神经肌肉疾病 (OR=7.02),心血管疾病 (OR=5.47),H1N1 pdm09亚型 (OR=2.29) 和高病毒载量 (OR=1.43).
*从这些预测因素开发的预后得分显示在预测ICU入院时具有高性能 (AUC=0.812).
* 预后得分在预测ICU入院时,单独优于病毒载量.

结论:

*病毒和宿主因素显著预测IFA感染个体的疾病严重程度.
* 开发的预后得分有效预测IFA患者的ICU入院情况.
* 在广泛临床实施之前,建议在较大人群中进一步验证.

关键词:

这种 IL-28B 类型的病毒.标签: 标签标签标签标签标签标签流感 A 是一种流感.萨里·萨里是什么意思获得得分的得分.病毒载量病毒载量

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