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Updated: Jul 9, 2025

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
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Published on: November 1, 2011

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非编码突变导致超强增强器重定位,导致B细胞淋巴瘤进展期间蛋白质合成失调

Rebecca J Leeman-Neill1,2, Dong Song3,4, Jonathan Bizarro1

  • 1Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.

Nature genetics
|December 4, 2023
PubMed
概括

基因组的改变驱动淋巴瘤的进展. 调节性DNA中的非编码突变会影响基因表达和rRNA处理,导致淋巴瘤细胞的瘤变化.

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