在癌症干部和分化中的BMP信号
Wei Zhou1, Kun Yan2, Qiaoran Xi3,4
1State Key Laboratory of Molecular Oncology, MOE Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Cell regeneration (London, England)
|December 4, 2023
概括
骨形态遗传蛋白 (BMP) 信号影响癌症的发展和进展. 了解其在癌症干细胞和瘤微环境中的双重作用是开发向疗法的关键.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 发展生物学 发展生物学
背景情况:
- 骨形态遗传蛋白 (BMP) 信号传递对发育和恒常状态至关重要.
- BMP信号在癌症中具有上下文依赖的作用,同时起到瘤抑制剂和促进剂的作用.
- 癌症干细胞 (CSCs) 驱动瘤生长,抵抗和复发,使其调节成为治疗目标.
研究的目的:
- 探索BMP信号在各种癌症中的多方面的作用.
- 阐明BMP信号在癌症干细胞调节和瘤微环境中的作用.
- 突出针对瘤学中BMP信号的治疗潜力.
主要方法:
- 文献综述和现有关于癌症中BMP信号传导的研究的综合.
- 分析BMP通路在CSC自我更新,分化,迁移,入侵和转移中的参与.
- 检查BMP信号在各种癌症类型中的作用,包括GBM,DIPG,结肠直肠,AML,肺,前列腺和骨髓瘤.
主要成果:
- BMP信号极为关键地调节了CSC的自我更新和差异化.
- 该途径影响瘤细胞迁移,入侵和转移.
- 在不同癌症类型中,BMP信号传递的作用各不相同,表现出抑制瘤和促进瘤的活动.
结论:
- 针对BMP信号提供了一个有希望的治疗途径,用于各种癌症.
- 对BMP通路机制的进一步研究对于开发精确,量身定制的癌症治疗是必不可少的.
- 利用BMP信号的双重性质可以帮助对抗瘤的进展和抵抗.
相关概念视频
02:40Cancer Stem Cells and Tumor Maintenance
4.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K
01:19Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
03:14Notch Signaling Pathway
4.3K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.3K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
02:33Hedgehog Signaling Pathway
7.4K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.4K