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难以入睡的失眠患者区域自发神经元活动和功能连接的异常变化:休息状态fMRI研究

Tongfei Jiang¹, Xuejiao Yin¹, Liying Zhu²

¹Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, 100010, China.

|December 4, 2023

概括

在失眠障碍中难以入睡与大脑活动的改变有关. 具体来说,右桃体和左后带状皮层之间的功能连接性增加与睡眠延迟相关.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
睡眠医学睡眠医学

背景情况:

失眠障碍 (ID) 显著影响日常生活,困难入睡是主要的抱怨.
在ID中延长睡眠延迟 (SL) 的潜在神经机制仍然不清楚.
这项研究研究了使用fMRI的ID患者的大脑活动和功能连接 (FC).

研究的目的:

探索延长睡眠延迟 (SL) 与自发神经活动的改变之间的关系.
检查失眠障碍 (ID) 患者大脑功能连接 (FC) 的变化.
使用fMRI识别潜在的神经相关的睡眠发作困难在ID.

主要方法:

休息状态的fMRI对52名ID患者和30名健康对照 (HC) 进行.
测量了低频波动 (ALFF) 的幅度,并分析了群体差异.
进行了基于种子的FC分析,并评估了临床特征 (SL,PSQI,HAMA,HAS) 和fMRI测量之间的相关性.

主要成果:

与HC相比,ID患者的PSQI,HAMA和HAS得分较高.
在左侧胰岛和右侧杏仁核中观察到ALFF的增加;在ID患者中,在右上侧顶叶 (SPL) 中发现ALFF的减少.
ID患者在左侧胰岛和双边前中心之间,以及右桃体和左后带状皮层 (PCC) 之间增加了FC;右桃体-左PCC FC的增加与SL.正相关.

结论:

在ID患者的右杏仁体,左胰岛和右SPL中发现了异常自发的神经波动.
在左侧胰岛前中心和右桃体左侧PCC区域观察到功能连接的增加.
长时间的睡眠延迟与与情绪相关的大脑区域的异常功能连接有关,特别是右桃体-左PCC.

关键词:

低频波动的幅度 (ALFF) 是指低频波动的幅度.功能连接 (FC) 功能连接功能性磁共振成像 (fMRI) 是一种功能性磁共振成像.过度兴奋过度兴奋失眠障碍是一种失眠障碍.睡眠延迟时间 (SL)

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