相关实验视频

Updated: Jul 9, 2025

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment

Published on: June 23, 2019

为艾滋病毒感染者进行肺移植:有前途的中期成果

Asher S Ralphs¹, Scott T Anderson^1,2, Blake T Langlais³

¹Department of Cardiothoracic Surgery, Mayo Clinic Arizona, Phoenix, AZ.

Transplantation

|December 5, 2023

概括

肺移植 (LTx) 是艾滋病毒感染者 (PLWH) 的可行选择,其存活率与艾滋病毒阴性患者相似. 这项研究支持LTx用于终末期肺部疾病的PLWH.

科学领域:

移植免疫学移植免疫学
传染性疾病传染性疾病
肺部病理学肺部病理学

背景情况:

预期寿命的增加导致艾滋病毒感染者 (PLWH) 患上更多的慢性疾病.
在PLWH中,末期肺病可能需要肺移植 (LTx),此前已有禁忌.
关于PLWH的LTx结果的数据有限.

研究的目的:

评估艾滋病毒感染者 (PLWH) 肺移植 (LTx) 的结果.
为了比较PLWH和HIV阴性肺移植接受者之间的生存率和术后并发症.

主要方法:

利用器官采购和移植网络 (OPTN) 的STAR文件来识别感染艾滋病毒的LTx接受者.
倾向性得分匹配创建了一个对照组的HIV阴性LTx接受者.
患者特征,移植参数,生存和术后结果的比较.

主要成果:

59名艾滋病毒感染的LTx接受者与236名HIV阴性对照者进行了比较.
PLWH具有较高的阳性细胞大脑病毒状态率,并获得更高的肺分配分数.
术后透析在PLWH中更常见,但整体并发症率和存活率相似 (1年:91.2%vs88.6%;3年:82.6%vs77.8%).

结论:

携带艾滋病毒的肺移植 (LTx) 接受者表现出与匹配的艾滋病毒阴性对照相比的生存率.
这些发现支持LTx作为终末期肺病PLWH的可行治疗选择.

更多相关视频

Orthotopic Left Lung Transplantation in Rats

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Published on: August 15, 2022

相关概念视频

Pulmonary Tuberculosis I

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...