在MS的thalamic缩量化:从多中心意大利神经成像网络倡议数据集到临床应用
Loredana Storelli1, Elisabetta Pagani1, Patrizia Pantano2,3
1From the Neuroimaging Research Unit (L.S., E.P., M.A.R., M.F.), Division of Neuroscience, Istituto Di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy.
AJNR. American journal of neuroradiology
|December 5, 2023
概括
对于多发性硬化症 (MS) 患者来说,FSL-MIST提供可靠的thalamic细分. 这种方法可以更好地检测体积变化,有助于临床实践.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 医疗图像分析 医学图像分析
背景情况:
- 甲状腺缩是多发性硬化症 (MS) 的早期指标,但尚未在临床上常规使用.
- 准确可靠的胸膜细分对于监测多发性硬化症进展至关重要.
研究的目的:
- 为了在MS中比较可靠的thalamic体积测量的自动细分方法.
- 为了评估细分软件的横截面和纵向性能.
主要方法:
- 分析了141名多发性硬化症患者和69名对照组的MRI图像.
- 三个软件程序 (FSL-FIRST,FSL-MIST,FreeSurfer) 进行了对比,用于胸膜细分.
- 分析包括横截面一致性,纵向可变性和效果大小.
主要成果:
- FSL-MIST和FSL-FIRST显示出基线 thalamic 容量的高度一致.
- FSL-MIST在对照组中显示了最高效果大小和最低的纵向变化.
- FSL-MIST需要最小的样本大小来检测变化.
结论:
- 在MS中,FSL-MIST提供了强大的多模式细分,用于准确的thalamic体积评估.
- 这种方法增强了检测微妙的乳头体积变化,支持临床应用.
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