固体瘤中的心脏功能障碍:范围审查
Bernadette Brady1,2, Alexandra Brown2, Michelle Barrett3
1Academic Department of Palliative Medicine, Our Lady's Hospice & Care Services, Dublin, Ireland bbrady@olh.ie.
BMJ supportive & palliative care
|December 5, 2023
概括
癌症可以独立于治疗对心脏造成伤害. 这项研究在癌症患者中发现了心肌病症和自主神经系统功能障碍等心血管异常,影响了预后并需要更广泛的查.
科学领域:
- 心脏瘤学 - 心脏瘤学
- 心血管医学 心血管医学
- 在瘤学瘤学.
背景情况:
- 癌症可以独立地损害心脏,与癌症治疗相关的心脏功能障碍 (CTRCD) 独立.
- 了解这些内在的心脏风险对于全面的患者护理至关重要.
研究的目的:
- 为了识别和表征心血管异常在成年患者有固体瘤,不包括CTRCD.
- 综合现有关于癌症相关心脏问题的性质和影响的证据.
主要方法:
- 在CINAHL,Embase和Medline数据库中进行了全面的范围审查,并补充了手动搜索.
- 在两个研究人员严格选和数据提取后,包括了44项研究.
- 由于鉴定的研究的异质性,采用了叙事综合.
主要成果:
- 确定的心血管异常包括心肌病变 (16项研究),自主神经系统功能障碍 (10项研究) 和生物标志物障碍 (9项研究).
- 这些异常与显著的发病率 (例如,胸痛,呼吸障碍,疲劳) 和更差的预后有关.
- 由于研究设计的变化,无法确定患病率.
结论:
- 心血管功能障碍发生在固体瘤恶性瘤中,独立于CTRCD,甚至在未经治疗的患者中.
- 症状包括心肌病,自主功能障碍和生物标志物升高,导致症状和生存率降低.
- 临床实践应整合这些发现,扩大查标准以解决内在心脏风险.
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