肺癌的脆弱性和预后:系统性审查和元分析
Tianzi Liu1, Xintong Peng1, Yan Geng1
1School of Clinical Medicine, Weifang Medical University, Weifang, Shandong, China.
脆弱性显著恶化了长期生存,并增加了肺癌患者的化疗毒性. 早期的脆弱性查和干预对于改善患者的结果和管理不良影响至关重要.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 临床研究 临床研究
背景情况:
- 肺癌是癌症死亡的主要原因之一.
- 虚弱是晚期肺癌的常见并发症,影响患者的预后.
- 脆弱性和肺癌的结果之间的关系需要进一步阐明.
研究的目的:
- 进行一项元分析,评估虚弱对肺癌预后的影响.
- 评估肺癌患者的脆弱性和短期化疗毒性之间的关联.
主要方法:
- 在PubMed,Embase,Web of Science和Cochrane Library数据库中进行系统的文献搜索,直到2022年12月.
- 包括遵守"柯克兰手册"指南的回顾性和前性研究.
- 使用Review Manager V.5.4进行的元分析,包括敏感性和子组分析.
主要成果:
- 虚弱肺癌患者的整体存活时间显著缩短 (HR 2.27) 和所有原因死亡率更高 (HR 1.63).
- 虚弱与化学疗法毒性 (OR 3.73) 的风险大幅增加有关.
- 敏感性分析证实了研究结果的稳定性和可靠性.
结论:
- 脆弱性对长期生存和肺癌中化疗毒性的发生率都有负面影响.
- 临床实践应包括肺癌患者的常规脆弱性查.
- 建议采取积极的脆弱性干预措施,以改善患者的治疗和治疗结果.
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