区域间突触输入是主要体感管皮层中与相关的活动的基础
Masahiro Kawatani1,2, Kayo Horio1, Mahito Ohkuma1
1Department of Physiology, Fujita Health University School of Medicine, Toyoake, 470-1192, Japan.
概括
身体运动会影响大脑活动. 研究人员发现,在皮过程中,感官皮层的处理依赖于乳头和二级体感官皮层的输入,而不是运动皮层的输入.
科学领域:
- 神经科学是一个神经科学.
- 感官处理 感官处理
- 发动机控制器的控制器
背景情况:
- 身体运动极大地影响整个大脑的神经元活动.
- 甲状腺皮层和运动感官通路与运动期间的感官皮层处理有关.
- 在感官皮层中为运动相关信号提供贡献的特定区域间电路仍然在很大程度上未被描述.
研究的目的:
- 为了研究在自发的鞭毛过程中,对胡须主体体感管皮质 (wS1) 的区域间输入的作用.
- 直接扰乱和评估抑制特定轴突投射对WS1.1中神经元活动的影响.
- 为了阐明胡须主要运动皮层 (wM1),胡须相关的丘脑 (wTLM) 和胡须次要体感皮层 (wS2) 在胡须时对wS1的输入.
主要方法:
- 利用一个G合的素,eOPN3,用于针对性抑制区域间信号.
- 记录了神经元活动,包括尖峰率和膜电位 (V) 动态,在自发鞭打期间醒着的雄性小鼠的wS1中.
- 将wM1,wTLM和wS2的抑制输入与wS1对与鞭毛相关的神经元活动的影响进行比较.
主要成果:
- 自发引发了WS1神经元发射速率和V动态的变化,包括脱极化和减小振荡.
- 抑制wM1输入到wS1并没有影响与接相关的尖峰速率或V动态.
- 对wS1的wTLM和wS2输入的抑制显著减弱了与whisking相关的V动态;wTLM沉默减少了相调调制,而wS2的抑制没有影响whisking变量调制.
结论:
- 在 wS1 中的感觉运动集成在自发的皮过程中主要通过直接的突触输入从与胡须相关的乳头 (wTLM) 和胡须二级体感皮质 (wS2) 进行介导.
- 从胡须主运动皮层 (wM1) 输入的信息在胡须时调节wS1活动中起到很小的作用.
- 泰拉马斯和二级体感皮质对于传递运动相关信息至关重要,这些信息在运动期间塑造感官处理.
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