肺功能测量对心血管风险的预测价值:一项大型前性队列研究
Lihui Zhou1, Hongxi Yang2, Yuan Zhang3
1School of Public Health, Tianjin Medical University, Tianjin, China.
Thorax
|December 5, 2023
概括
肺功能测量,如螺旋计,可以帮助预测心血管疾病 (CVD) 的风险. 纳入这些措施可以提高心血管疾病风险评估的准确性.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 心血管疾病 (CVD) 风险评估对于预防至关重要.
- 众所周知,肺功能测量与心血管疾病有关.
- 肺功能对心血管疾病风险的增量预测值仍在调查中.
研究的目的:
- 评估螺旋计参数对心血管疾病 (CVD) 风险的附加预测价值.
- 评估肺功能障碍 (限制性和阻塞性) 与心血管疾病结果之间的关联.
- 确定将肺功能整合到现有的心血管疾病风险预测模型中的临床效用.
主要方法:
- 分析了308,415名英国生物库参与者,他们之前没有心血管疾病.
- 使用了由QRISK3,ACC/AHA和SCORE模型定义的螺旋测量数据和心血管疾病结果.
- 采用Cox比例危险模型和决策曲线分析来评估预测能力.
主要成果:
- 在超过12.5年的时间里,螺旋测量参数显示了与心血管疾病的L形关联.
- 在所有预测模型中,限制性和阻塞性肺损伤显著增加了心血管疾病风险 (例如,调整后的HR从1.20到1.84不等).
- 在1s中整合非线性强迫呼气体积改善了心血管疾病风险预测,证明了净收益.
结论:
- 螺旋测量指标为心血管疾病风险评估提供了有价值的补充.
- 进一步的成本效益研究和临床试验是必要的,以将这些发现付诸实践.
- 临床医生应将肺功能作为综合心血管疾病风险评估的一部分.
关键词:
呼吸系统测量 呼吸系统测量相关概念视频
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