在Helicobacter pylori感染中使用含有比斯木斯的四重治疗的最佳治疗持续时间:一项回顾性研究
Ji Yoon Kim1, Sang Gyun Kim, Soo-Jeong Cho
1Department of Internal Medicine, Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Medicine
|December 5, 2023
概括
十天的含四倍疗法 (BQT) 有效地消灭了Helicobacter pylori,与14天的疗程相匹配,没有增加不良事件. 这为H. pylori感染提供了潜在的更短,同样有效的治疗方法.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 含四倍疗法 (BQT) 越来越多地用于消除Helicobacter pylori.
- 标准的BQT治疗持续时间为14天,但更长的疗程可能会增加不良事件.
- 为了平衡有效性和安全性,最佳的BQT持续时间需要进一步研究.
研究的目的:
- 为了比较7日,10日和14天的含有比斯的四重治疗方案的疗效和安全性,用于H. pylori根除.
- 确定BQT的最佳持续时间,以实现高根除率与最小的不良事件.
主要方法:
- 在首尔国立大学医院接受BQT治疗的328名患者的回顾性评估 (2010年1月 - 2022年5月).
- 患者被分为7天 (n=74),10天 (n=177) 和14天 (n=77) 的治疗组.
- 使用治疗意图 (ITT) 和每协议 (PP) 分析评估了根除率;还分析了不良事件.
主要成果:
- 每项协议分析显示,10天 (94.9%) 和14天 (92.5%) 疗程的根除率明显高于7天疗程 (84.1%).
- 在ITT和PP分析中,在10天和14天的BQT疗法之间没有观察到消除率的显著差异.
- 在所有治疗持续时间内,不良事件发生率是可比的 (P=.835).
结论:
- 十天的含有比斯木斯的四倍治疗方案与14天的治疗方案对H. pylori根除一样有效.
- 10天的BQT疗法实现了比7天疗法更高的根除率,但不增加不良事件.
- 十天的BQT代表了最优的持续时间,提供与14天治疗相当的疗效,并可能改善耐受性.
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