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TREM1作为一种新的预后生物标志物和瘤免疫微环境评估器在质瘤中

Qin Lu¹, Yonglin Xie², Xuchen Qi¹

¹Department of Neurosurgery, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.

|December 5, 2023

概括

在骨髓细胞1 (TREM1) 上表达的触发受体在质瘤中升高,与预后不佳和晚期疾病相关. 这种免疫调节器影响瘤微环境,为诊断和预后生物标志物提供潜力.

科学领域:

神经瘤学神经瘤学
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

质瘤是一种恶性脑瘤,预后不好.
瘤免疫微环境对质瘤的发展和进展至关重要.
在质瘤中TREM1 (在骨髓细胞1表达的触发受体) 的作用仍然未被探索.

研究的目的:

调查TREM1在质瘤预后中的作用.
分析TREM1与质瘤瘤免疫微环境之间的关联.

主要方法:

使用TCGA和GEO数据库进行TREM1mRNA表达分析.
进行了考克斯回归,卡普兰-梅尔,GO,KEGG,估计,时间和斯皮尔曼相关性分析.
与临床病理特征相关的TREM1表达,整体存活率 (OS),免疫细胞透和免疫检查点.

主要成果:

在质瘤中,TREM1表达显著增加.
较高的TREM1水平与更糟糕的预后相关,WHO高级,IDH野生型状态和1p/19q非codeletion.
与TREM1共同表达的基因与免疫调节和炎症反应有关.
TREM1通过调节免疫细胞透和免疫检查点表达来影响质瘤的进展.

结论:

在质瘤中,TREM1被上调,并作为一个重要的预后生物标志物.
TREM1影响质瘤免疫微环境,影响免疫细胞透和免疫检查点.
在质瘤患者中,TREM1显示出作为临床结果和病理特征的新型预测因子的潜力.

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