高压氧气治疗和Risperidone对自闭症儿童的治疗影响:一项临床试验
Asmaa S Mohamed1, Hosam M Ahmad2, Ahmed A Abdelrahman3
1Department of Clinical Pharmacy, Faculty of Pharmacy, Deraya University, Minia, Egypt.
Basic and clinical neuroscience
|December 5, 2023
概括
高压氧疗法 (HBOT) 和瑞斯佩里都有效地治疗儿童的核心自闭症症状. 在这项随机临床试验中,HBOT与RISPERIDONE相比显示出更好的结果.
科学领域:
- 儿科神经学 儿科神经学
- 发育儿科 发育儿科
- 临床试验 临床试验
背景情况:
- 自闭症谱系障碍 (ASD) 的核心症状带来了重大挑战.
- 对ASD的长期药物治疗可能会导致副作用和合规问题.
- 像高压氧疗法 (HBOT) 这样的替代疗法正在探索ASD治疗.
研究的目的:
- 为了研究HBOT和RISPERIDONE对儿童核心自闭症症状的影响.
- 为了比较HBOT与RISPERIDONE在治疗ASD方面的疗效.
主要方法:
- 一个随机的,受控的临床试验,涉及180名患有ASD的儿童 (5-8岁).
- 三组接受了:40个HBOT疗程,素 (0.25-0.5毫克/天) 或安慰剂6个月.
- 评估使用了儿童自闭症评级表 (CARS) 和自闭症治疗评估清单 (ATEC) 在基线和一年.
主要成果:
- 一年后,所有组的CARS和ATEC分数都显著改善.
- 第一组 (HBOT) 和第二组 (RISPERIDONE) 显示出比对照组 (第三组) 更大的改善.
- 与Risperidone和安慰剂相比,HBOT在核心自闭症症状中取得了最显著的改善.
结论:
- 无论是HBOT还是Risperidone都是有效的非药物和药物治疗方法,用于治疗ASD核心症状.
- HBOT提供了一个有前途的替代或辅助疗法,显示出比RISPERIDONE更好的结果.
- 对非传统治疗方法的进一步研究,如对ASD的HBOT,是有必要的.
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