体重指数升高会降低对SARS-CoV-2感染的幽默反应
Marcus Zw Tong1, Julian Dj Sng1, Meagan Carney2
1School of Chemistry and Molecular Biosciences The University of Queensland St Lucia QLD Australia.
Clinical & translational immunology
|December 5, 2023
概括
体重指数 (BMI) 升高会影响对SARS-CoV-2感染的免疫反应,降低抗体水平和B细胞功能. 对于BMI为25kg/m2或更高的个体,建议接种疫苗,而不是依赖感染诱导的免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 第三类肥胖 (BMI ≥40 kg/m2) 会影响SARS-CoV-2疫苗接种反应.
- 高BMI (≥25 kg/m2) 对SARS-CoV-2感染和接种疫苗的幽默免疫力的影响尚不清楚.
研究的目的:
- 研究SARS-CoV-2感染和接种疫苗后高BMI和幽默性免疫反应之间的关联.
主要方法:
- 在SARS-CoV-2感染后3个月和13个月收集的血液样本 (未接种疫苗).
- 血液样本是在第二剂COVID-19疫苗接种5个月后采集的 (主要是先前感染的).
- 测量了幽默反应,比较BMI<25 kg/m2的个人与BMI≥25 kg/m2的个人.
主要成果:
- 增加的BMI (≥25 kg/m2) 与感染后抗体反应减少有关,包括3个月后较低的标位.
- 感染后13个月,增加的BMI与降低的抗体狂热度和较少的尖端特异性B细胞有关.
- 在接种疫苗5个月后,高BMI和幽默免疫力之间没有发现显著的关联.
结论:
- 体重指数升高与感染诱导的SARS-CoV-2幽默免疫力受损有关.
- 这表明接种疫苗对于BMI较高的人来说至关重要,而不是依靠自然感染来获得免疫力.
相关概念视频
Humoral Immune Responses
72.8K
Overview
72.8K
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
Pulmonary Tuberculosis I
244
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
244
Obesity
507
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
507
Vaccinations
44.6K
Overview
44.6K


