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miR-146a调节了两个小鼠模型肺部的肺形成和异常炎症

Hitomi Yoshikawa1, Tadashi Sato1, Kimiko Horikoshi1

  • 1Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

American journal of physiology. Lung cellular and molecular physiology
|December 5, 2023
PubMed
概括

在小鼠模型中,microRNA-146a (miR-146a) 能保护小鼠免受肺气和炎症的影响. 在慢性阻塞性肺病 (COPD) 模型中,miR-146a的损失会加剧肺损伤和炎症反应.

关键词:
慢性阻塞性肺病 慢性阻塞性肺病突发性质炎症是什么意思这是一种炎症炎症炎症炎症.在 miR-146a 里面.这是一个微型RNA.

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Chronic Obstructive Pulmonary Disease II: Emphysema

Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.