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对半固体挤出3D打印油墨配方对印刷固体剂型表单性能的影响进行调查

Bin Zhang^1,2, Peter Belton³, Xin Yi Teoh^1,4

¹School of Pharmacy, University of East Anglia, Norwich, UK. sheng.qi@uea.ac.uk.

Journal of materials chemistry. B

|December 5, 2023

概括

半固体挤出3D打印显示了个性化药品制造的前景. 氧化的添加增强了药片形状的真实性,并加速了药物释放,特别是对.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
增材制造增材制造增材制造

背景情况:

半固体挤出 (SSE) 3D打印正在出现,用于个性化的固体剂型,特别是对于热敏药物,由于环境温度处理.
了解配方组件对油墨打印能力和最终平板电脑质量的影响,对于优化 SSE 3D 打印过程至关重要.

研究的目的:

为了研究聚合物组成 (HPMC,HPMC+PVP),二氧化 (SiO2) 作为分解剂,以及活性药物成分 (酸,) 对SSE3D打印的影响.
评估半固体油墨的可打印性以及SSE 3D打印片的物理化学特性和体外药物释放.

主要方法:

配制具有不同聚合物成分,二氧化和活性药物成分的半固体油墨.
油墨的风学特征与可打印性相关联.
对SSE3D打印片的物理化学表征和体外药物释放研究.

主要成果:

添加二氧化可以通过改变油墨形学来提高3D打印的形状保真度,并显著增加打印孔隙性 (从47.6%增加到70.3%).
随着SiO2的结合,降醇的药物释放量显著增加 (p < 0.05),可能是由于增强的多孔性和其分解性质.
活性药物成分的水溶性和与聚合物系统的相互作用影响了结构忠实性和药物释放性能.

结论:

二氧化是SSE3D打印中的一个有价值的添加剂,用于增强形状忠实性和加速打印平板电脑中的药物释放.
配方设计,包括聚合物选择和添加剂选择,对SSE 3D打印剂型的可打印性和药物释放特性产生重大影响.
SSE 3D 打印提供了一个可行的平台,用于制造个性化的固体剂型,具有可调节的药物释放配置文件.

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