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Updated: Jul 9, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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作为潜在的nAChR调节器的新型1,2,4-Triazolone衍生物的基于目标的设计,合成和生物评估

Xingxing Lu1, Huan Xu1, Xiaoming Zhang1

  • 1Innovation Center of Pesticide Research, Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China.

Journal of agricultural and food chemistry
|December 5, 2023
PubMed
概括

研究人员开发了一种新模型来设计针对尼古丁乙胆受体 (nAChR) 的新型杀虫剂. 这导致了强大的化合物4k和4q,它们对大豆虫有很高的疗效,对蜜蜂的毒性很低.

关键词:
1,2,4-triazolone衍生品的1,2,4-triazolone衍生品的使用情况乙烯基胆结合蛋白是一种结合蛋白.杀虫活动 杀虫活动尼古丁酸乙胆受体调节剂 尼古丁酸乙胆受体调节剂基于目标的药物设计.

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