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描述肠道病毒C96的基因组和植物动力学分析

Tingting Yang^1,2,3, Qiang Sun^2,3, Dongmei Yan^2,3

¹School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.

Journal of medical virology

|December 5, 2023

概括

肠道病毒C96 (EV-C96) 在肠道病毒C物种中显示出显著的遗传变异和潜在的重组. 这项研究为全球了解EV-C96分子流行病学提供了关键的基因组数据.

科学领域:

病毒学病毒学
分子流行病学分子流行病学
基因组学就是基因组学.

背景情况:

肠道病毒C96 (EV-C96) 是最近在肠道病毒C物种中发现的一种血清型.
在各种临床和环境样本中检测到EV-C96,包括急性性和手足口腔疾病患者的样本.
有限的全基因组数据阻碍了对EV-C96.6的全面分子流行病学研究.

研究的目的:

使用新收集的和现有的基因组数据对EV-C96进行全面的分子流行病学分析.
研究EV-C96.6的遗传多样性,进化速度和潜在的重组事件.
为未来的全球EV-C96研究提供宝贵的基因组数据.

主要方法:

在中国收集的罕见EV-C96菌株的全基因组测序和分析 (1997-2020).
用GenBank.C96的现有EV-C96基因组进行比较序列分析.
遗传学分析以确定遗传变异,进化速率和最近的共同祖先 (MRCA).
重组分析以确定EV-C96.6的潜在来源.

主要成果:

EV-C96表现出显著的遗传变异,与原型菌株的核酸和氨基酸相似性分别在75%-81.8%和85%-94.9%之间.
在EV-C96.6中确定了15个不同的基因组.
平均进化速率估计为5.16×10-3个替代/地点/年,MRCA的日期为1925年.
重组分析表明,EV-C96可能是EV-C组内的重组菌株,特别是在非结构性蛋白质编码区域.

结论:

EV-C96具有高度的遗传多样性和复杂的进化历史.
这些发现表明,EV-C96的潜在重组起源可能涉及其他肠道病毒C血清型.
这项研究显著扩大了EV-C96的基因组数据库,为全球分子流行病学和公共卫生监测提供了关键的见解.

关键词:

肠道病毒C96 进化分析是一种进化分析.基因型定制是基因型定制.再组合的复合方式.传输动态分析传输动态分析

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