皮质类固醇用于预防后神经疼痛
Xin Jiang1, Yanbo Li1, Ning Chen1
1Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
The Cochrane database of systematic reviews
|December 5, 2023
概括
皮质类固醇在预防后神经疼痛 (PHN) 的有效性仍然不确定,因为证据的确定性非常低. 皮质类固醇在急性疹患者的不良事件中几乎没有差异.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 后神经疼痛 (PHN) 是疹的一个衰弱的并发症.
- 皮质类固醇具有抗炎性质,具有潜在的治疗益处.
- 本综述是对皮质类固醇在PHN预防中的有效性的最新分析.
研究的目的:
- 评估皮质类固醇在预防PHN的益处和危害.
- 综合来自随机对照试验 (RCT) 关于使用皮质类固醇预防PHN的证据.
主要方法:
- 在2022年6月之前,对多个数据库和试验注册表进行全面搜索.
- 包括RCT比较皮质类固醇 (口服,肌内,静脉注射) 与安慰剂或没有治疗急性疹治疗.
- 独立的数据提取,偏差风险评估和证据评估的确定性由两名审查员进行.
主要成果:
- 包括5个RCT和787名参与者;没有新的研究被确定为此更新.
- 关于口服皮质类固醇在六个月后预防PHN的影响的证据非常不确定 (RR 0.95,95%CI 0.45至1.99).
- 在皮质类固醇和安慰剂组之间没有观察到严重或非严重不良事件的显著差异.
结论:
- 目前的证据不足以确定口服皮质类固醇在预防PHN方面的疗效.
- 皮质类固醇似乎对急性疹中不良事件的影响很小.
- 未来的研究应该包括长期随访和生活质量措施,以评估皮质类固醇对PHN的影响.
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