乌灵感的光响应抗菌微粒与天然黑色素纳米颗粒喷雾
Chuanhui Song1, Xiangyi Wu1, Yu Wang1
1Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Small (Weinheim an der Bergstrasse, Germany)
|December 5, 2023
概括
受乌鱼墨水的启发,新型热敏微粒可为牙周炎治疗提供黑色素纳米颗粒. 这些颗粒提供受控释放和强大的光热抗菌活性对P. gingivalis.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 牙周病学 牙周病学
背景情况:
- 对牙周炎的局部抗生素的控制仍然是一个挑战.
- 黑色素纳米粒子 (NP) 显示出作为具有抗炎性质的光热剂的前景.
- 乌鱼的墨水驱逐激发了新的药物递送机制.
研究的目的:
- 开发用于牙周炎治疗的具有热敏度的黑色素集成多孔微粒 (MPs).
- 通过近红外辐射 (NIR) 实现黑色素NP的受控释放.
- 评估开发的MPs的抗菌和抗炎疗效.
主要方法:
- 黑色素集成多孔微粒 (MP) 的微流体合成,由黑色素NP,聚N-异烯胺 (PNIPAM) 和亚加组成.
- 使用NIR辐射触发黑色素NP的热能转换,导致糖化和PNIPAM诱导的微球收缩以控制释放.
- 在体外和体内对抗 Porphyromonas gingivalis 的抗菌活性和抗炎作用的评估.
主要成果:
- 成功合成了具有高黑色素NP负载和生物相容性的热响应MPs.
- 通过光热效应在NIR照射时,证明了黑色素NP的受控释放.
- 对P. gingivalis表现出强大的光热抗菌活性,并在体内具有显著的抗炎性质.
- 在治疗受感染的伤口和牙周炎模型中得到证实的疗效.
结论:
- 灵感来自鱼的光响应抗菌MP提供了一种新的,可控释放药物递送系统.
- 在MPs中的黑色素NP提供有效的光热抗菌作用和抗炎益处.
- 这项技术在牙周炎和其他抗菌治疗中具有显著的临床应用潜力.
相关概念视频
01:26Defense Mechanism Against Infection
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
01:18Surface Membrane Barriers
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
01:31Defense Against Bacterial Pathogens
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
01:26Physical Methods for Controlling Microbial Growth: Radiation and Filtration
Radiation and filtration are essential tools for microbial control, targeting microorganisms through distinct mechanisms. Radiation eliminates microbes by damaging their DNA, either killing them or inhibiting their growth. Based on wavelength, radiation is classified into two types: nonionizing and ionizing radiation.Non-ionizing radiation, such as UV radiation (200–400 nm), is absorbed by DNA, causing defects that effectively disinfect surfaces, air, and water, including safety cabinets.
01:28Antimicrobial Effectiveness
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
01:24iChip
The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...