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沙门氏菌积极调节小鼠巨细胞中的TFEB,以增长阶段和时间依赖的方式

Subothan Inpanathan^1,2, Erika Ospina-Escobar^1,2, Vanessa Cruz Li¹

¹Department of Chemistry and Biology, Toronto Metropolitan University , Toronto, Ontario, Canada.

Microbiology spectrum

|December 5, 2023

概括

沙门氏菌细菌操纵宿主转录因子TFEB以控制其细胞内生长. 细菌是一种细菌.

科学领域:

细胞生物学细胞生物学
微生物学微生物学
宿主-病原体相互作用

背景情况:

转录因子TFEB (转录因子EB) 调节细胞应激反应,包括溶酶体生物发生,自和免疫基因表达.
一般来说,TFEB激活被认为是对抗饥饿和感染等压力的宿主保护机制.
在沙门氏菌感染期间TFEB的作用是有争议的,关于沙门氏菌是否促进或抑制TFEB的报道是相互矛盾的.

研究的目的:

调查在细胞内感染期间沙门氏菌对TFEB的时空调节.
调和有关沙门氏菌对TFEB的影响的相互矛盾的观察.
了解沙门氏菌对TFEB操纵的功能意义.

主要方法:

哺乳动物细胞在不同生长阶段感染沙门氏菌 (静止或晚期).
感染后TFEB激活状态的分析.
在改变TFEB法规的条件下对细菌生长的评估.

主要成果:

静止阶段的沙门氏菌在感染后延迟TFEB的激活.
晚期寄存期沙门氏菌允许TFEB激活.
破坏沙门氏菌对TFEB的条件控制可能对细菌有害.

结论:

沙门氏菌对宿主TFEB激活具有条件控制,这取决于其生长阶段.
这种操纵可能有助于促进细胞内细菌的生长.
了解这种宿主-病原体相互作用为治疗干预提供了潜在的途径.

关键词:

沙门氏菌是一种沙门氏菌.细菌细菌细菌是一种细菌.细胞适应细胞适应文化文化文化文化具有天生的免疫力.lysosomes 溶解体溶解体是一种溶解体.巨细胞是什么?巨细胞是什么?转录因子是一种转录因子.

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