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Updated: Jul 9, 2025

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基于N-基氧胺的生物对等酸陷的表征

Daniel Lee1, Simon Latour2,3, Michael Emblem1

  • 1Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.

Bioconjugate chemistry
|December 5, 2023
PubMed
概括

这项研究引入了一种新的生物对等反应,将子和化物结合起来,形成稳定的双循环异索利丁. 这种高效的反应在细胞溶解物和细胞表面起作用,扩大了生物对等化学工具.

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Nitriles to Ketones: Grignard Reaction

Organomagnesium halides, commonly known as Grignard reagents, convert nitriles to ketones and proceed through a nucleophilic acyl substitution. Nitriles react with a Grignard reagent, followed by an aqueous acid, to yield ketones. The reaction introduces a new carbon–carbon bond. The alkyl–magnesium bond in the Grignard reagent is highly polar, so the alkyl carbon develops a carbanionic character and acts as a nucleophile.
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