饮食障碍和酒精参与在晚期青少年双胞胎的维度之间的不同遗传关联
Baiyu Qi1, Laura M Thornton2, Courtney E Breiner3
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Alcohol, clinical & experimental research
|December 5, 2023
概括
遗传因素显著影响女性青少年的饮食障碍和酒精参与. 了解这些共同的遗传联系对于开发针对性干预治疗并发性疾病至关重要.
科学领域:
- 精神病学是一个精神病学.
- 行为遗传学 行为遗传学
- 青少年健康 青少年健康
背景情况:
- 双胞胎研究表明,在成人和青少年中,共同的遗传和环境影响导致饮食障碍和酒精使用.
- 有限的研究已经探索了这些关联在青少年晚期,特别是在两性和各种饮食障碍和酒精参与的维度.
研究的目的:
- 在青春晚期双胞胎中调查特定的饮食障碍尺寸和酒精参与子尺度之间的遗传和环境相关性.
- 检查这些相关性中的性别差异.
主要方法:
- 利用了来自瑞典儿童和青少年双胞胎研究中的3568名18岁女性和2526名男性同性双胞胎的数据.
- 使用饮食障碍清单-2 (EDI) 评估饮食障碍的尺寸 (驱动瘦身,嗜食,身体不满).
- 使用酒精使用障碍识别测试消费 (AUDIT-C) 和问题 (AUDIT-P) 分量表来衡量酒精参与.
主要成果:
- 表型和双胞胎相关性仅在雌性双胞胎中显著,附加遗传因素解释了50-64%的差异.
- 在食欲不良 (EDI) 和酒精问题 (AUDIT-P) (r_a = 0.46) 之间观察到最强的遗传相关性.
- 非共享的环境相关性通常很低,从0.03到0.13不等.
结论:
- 显而易见的遗传和环境模式将女性与男性青少年的饮食障碍和酒精参与联系在一起.
- 研究结果支持对有伴随性饮食障碍和酒精使用障碍的晚期青少年进行性别特定治疗策略的需要.
- 强调在那些有酒精问题的人中评估饮食障碍的家族史,反之亦然,以改善检测和治疗.
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