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儿童和青少年生长障碍的治疗方法
Joachim Woelfle1, Dirk Schnabel, Gerhard Binder
1Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen; Centre for Chronic Sick Children, Paediatric Endocrinology, Charité, University Medicine Berlin, Berlin; Pediatric Endocrinology, University Children's Hospital, Universiy of Tuebingen, Tuebingen.
新的治疗方法为患有生长障碍的儿童提供了希望,包括复合生长激素治疗缺陷和Vosoritide治疗軟骨發育不良. 由于治疗方法不断发展,医生必须与家人讨论治疗目标和期望.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 增长激素治疗疗法 增长激素治疗
- 骨发育不良症 骨发育不良症
背景情况:
- 大约3%的儿童经历了异常矮身,3%的儿童经历了异常高身.
- 医学科学的进步扩大了对生长障碍的治疗可能性.
研究的目的:
- 对儿科生长障碍的当前和新兴治疗方案进行审查.
- 讨论新的治疗方法对矮身和高身的影响.
主要方法:
- 选择性的文献评论. 选择性的文献评论.
- 纳入作者临床专业知识.
主要成果:
- 重组人体生长激素 (rhGH) 是缺陷垂体生长激素的标准;长效版本正在出现.
- 沃索里提德 (CNP类似物) 已被批准用于治疗无双质形成症;重组胰岛素类生长因子1 (IGF-1) 治疗严重的IGF-1缺乏症.
- 对于高个体的增长减弱治疗和社会观念的安全数据不断变化,正在改变管理策略.
结论:
- 新的治疗方法解决了罕见的矮身原因;最新的安全信息促使对高个体的外科手术进行重新评估.
- 对于一些新疗法,包括超生理生长激素 (GH) 疗法,缺乏关于成人身高结果的可靠数据.
- 知情同意至关重要,需要医生和患者/家属之间详细讨论治疗期望和可实现的目标.
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