在实体器官移植后的儿科淋巴增殖性疾病的临床病理谱
Jinjun Cheng1, Birte Wistinghausen1
1From the Department of Pathology and Laboratory Medicine (Cheng), Center for Cancer and Blood Disorders (Wistinghausen), and Center for Cancer and Immunology Research (Cheng, Wistinghausen), Children's National Hospital, Washington, District of Columbia.
Archives of pathology & laboratory medicine
|December 5, 2023
概括
移植后淋巴增殖障碍 (PTLD) 是儿科固体器官移植 (SOT) 后的一种严重并发症. 这篇评论分析了PTLD.
科学领域:
- 儿科瘤学 儿科瘤学
- 移植免疫学 移植免疫学
- 血液病理学 血液病理学
背景情况:
- 移植后淋巴增殖障碍 (PTLD) 是儿科固体器官移植 (SOT) 后的一个重大并发症.
- 大多数PTLD是埃普斯坦-巴尔病毒 (EBV) 驱动的CD20+B细胞增殖,通常对免疫抑制降低和抗CD20免疫疗法做出反应.
- 由于发病率低,存在有限的前性研究,这阻碍了对儿科患者群体的全面理解.
研究的目的:
- 为儿童SOT接受者提供PTLD的综合分析.
- 检查儿童,青少年和年轻人的PTLD的临床,形态和分子遗传特征.
- 为了解决有关儿科PTLD的知识差距.
主要方法:
- 个人经验的回顾.
- 从PubMed. 的出版作品的分析.
主要成果:
- PTLD涵盖了从非恶性扩散到淋巴瘤的异质谱.
- 虽然大多数儿科PTLD都是EBV阳性,但EBV阴性病例越来越多.
- 病理学分类已经发展,但需要进一步的研究.
结论:
- PTLD的分类和理解正在不断发展.
- 进一步的研究对于识别高风险患者和优化复发/耐药性疾病的治疗至关重要.
- 阐明PTLD生物学对于改善患者的治疗结果至关重要.
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