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血清IL-17和TNFα作为系统性硬化症患者的预后生物标志物:一项前性研究

Joanna Kosałka-Węgiel^1,2,3, Sabina Lichołai⁴, Renata Pacholczak-Madej^5,6

¹Rheumatology and Immunology Clinical Department, University Hospital, Krakow, Poland. joanna.kosalka@uj.edu.pl.

Rheumatology international

|December 5, 2023

概括

系统性硬化症 (SSc) 患者表现出较高的瘤坏死因子-α (TNFα) 水平,与癌症风险增加有关. 升高的介质素-17 (IL-17) 可能表明SSc患者的预后较差.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
在瘤学瘤学.

背景情况:

内皮损伤是系统性硬化症 (SSc) 发病的一个关键因素,与炎症生物标志物升高相关.
循环细胞因子在SSc中发挥作用,但它们与临床表现和长期结果的特定关联需要进一步调查.

研究的目的:

分析SSc患者和对照者的血清细胞因子度.
评估细胞因子,SSc临床特征和长期疾病过程之间的关系,包括生存率和癌症患病率.

主要方法:

瘤坏死因子-α (TNFα),干扰素- (IFNγ),介质素-4 (IL-4),IL-6,IL-10,IL-17和纤维细胞激活蛋白 (FAP) 的血清水平在43名SSc患者和24名健康对照中被测量.
在SSc患者中,TNFA基因促进区 (rs361525,rs1800629,rs1799964,rs1799724) 的四个单核酸多态 (SNP) 被基因定型.
临床数据和长期结果 (癌症发病率,死亡率) 在中位数为5年的随访期内收集.

主要成果:

与对照组相比,SSc患者的血清TNFα水平显著提高 (17%的增加);其他细胞因子在组或SSc亚型之间没有显著差异.
在SSc患者中,较高的IL-17水平与左心室喷射率的降低有关.
在随访期间,较高的TNFα与癌症患病率增加有关,而较高的IL-17与较高的死亡风险相关.
特定的TNFA基因多态 (AG rs361525,CT rs1799964) 与癌症风险增加有关.

结论:

血清TNFα升高是SSc的特征生物标志物,特别与癌症发展有关.
增加IL-17水平可能作为SSc患者预后不佳的预测标记.
TNFA基因多态可能会影响SSc患者的癌症风险,需要进一步调查.

关键词:

生物标志物生物标志物癌症癌症癌症癌症细胞因子 (cytokines) 是一种细胞因子.介质蛋白 17 介质蛋白 17 系统性硬化症系统性硬化症瘤亡因子-阿尔法

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