多重低强度血管与单次皮质下心脏病发作患者的认知障碍有关
Tang Yang1, Pengfei Peng2, Shuai Jiang1
1Department of Neurology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, China.
Translational stroke research
|December 5, 2023
概括
多重低强度血管,包括深髓静脉 (DMVs) 和皮质静脉 (CVs),与单次皮质下心脏病发作 (SSI) 患者的认知功能有关. 这些关联在与分支动脉瘤疾病 (BAD) 相关的SSI中更为强烈.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 认知科学 认知科学
背景情况:
- 单次皮质下心脏病发作 (SSI) 可以导致认知障碍.
- 大脑静脉异常在SSI后认知衰退中的作用尚未完全理解.
- 了解这些关系可以为中风后认知功能障碍提供有针对性的干预措施.
研究的目的:
- 调查多重低强度血管 (DMV和CV) 与急性SSI患者的认知功能之间的关联.
- 探索SSI不同病因机制 (BAD与CSVD) 对这种关系的影响.
- 提供关于SSI后认知障碍病理生理学的见解.
主要方法:
- 在103名急性SSI患者中评估深髓静脉 (DMVs) 和皮层静脉 (CVs) 评分,使用全脑血管壁MRI.
- 使用蒙特利尔认知评估 (MoCA),形状痕迹测试 (STT) 和Stroop颜色和文字测试 (SCWT) 评估认知功能.
- 将SSI病因二分化为分支动脉瘤性疾病 (BAD) 和与SSI相关的脑小血管疾病 (CSVD).
主要成果:
- 在SSI患者中,较高的DMV得分与STT-B和STT-B-1分钟的表现较差相关.
- 在SSI患者中,较高的CVs得分与STT-A的表现较差相关.
- 与CSVD相关的SSI相比,BAD患者的DMV/CVs得分与认知功能之间的关联显著更明显.
结论:
- 多重低强度血管,特别是DMV和CV,与SSI患者的多域认知障碍有关.
- SSI的病因机制,特别是BAD,影响了这些关联的强度.
- 对静脉变化的进一步研究对于理解和管理中风后认知障碍至关重要.
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