接受索马托他类型治疗的神经内分泌瘤患者的紧急胆固醇切除术可能会导致并发症
Annali italiani di chirurgia
|December 5, 2023
概括
对神经内分泌瘤的长期索马托斯塔丁类比治疗可以增加患胆囊结石和并发症的风险. 在初始手术期间预防性胆囊切除可能会防止未来对胆结石的紧急手术.
科学领域:
- 胃肠道学和瘤学
- 内分泌学 在内分泌学.
背景情况:
- 神经内分泌瘤 (NETs) 的发病率正在上升,手术和体静止素类似物作为高分泌形式的标准治疗.
- 索马托斯塔丁类似物有效控制症状,并改善NET患者的存活率.
研究的目的:
- 评估经神经内分泌瘤手术后接受索马托斯坦类药物治疗的患者的胆囊化及其并发症的发生率.
主要方法:
- 对四名患有NET的成年患者 (胃,尾,大肠) 进行了回顾性分析,这些患者接受了长期的索马托斯坦类同类疗法.
- 患者以前没有胆结石史,但由于并发症需要紧急胆囊切除术.
主要成果:
- 所有患者都出现了症状的胆囊结石,需要紧急手术.
- 并发症包括急性胆囊炎,性胆囊炎和肠道阻塞.
结论:
- 索马托斯塔丁类似物可能会损害胆囊的运动性,导致胆结石的形成.
- 在初始NET手术期间的预防性胆囊切除术可以预防胆结石的紧急胆囊手术.
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