在阻塞性睡眠呼吸暂停患者中,客观睡眠时间和全因死亡率
Yiqi Lin1, Yongxi Wu1, Qianwen Lin1
1Department of Sleep Center, Fujian Provincial Hospital, Shengli Clinical Medical College, Fujian Medical University, Fuzhou, China.
JAMA network open
|December 5, 2023
概括
阻塞性睡眠呼吸暂停 (OSA) 患者的睡眠时间缩短与全因死亡风险增加有关. 即使是适度减少睡眠时间,客观地测量,也会提高死亡风险,而不依赖于呼吸暂停的严重程度.
科学领域:
- 睡眠医学 睡眠医学
- 心血管健康 心血管健康
- 公共卫生 公共卫生
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 患者的睡眠持续时间和死亡率之间的关系尚未得到充分证实.
- 阻塞性睡眠呼吸暂停是一种常见的疾病,与各种健康风险有关.
研究的目的:
- 研究被诊断患有OSA的个体的客观睡眠持续时间和全因死亡率之间的关联.
- 为了确定睡眠持续时间是否影响死亡风险,独立于OSA严重程度 (呼吸暂停-呼吸暂停指数).
主要方法:
- 一项使用睡眠心脏健康研究 (SHHS) 数据的队列研究,涉及2574名患有OSA的参与者.
- 客观睡眠时间使用多睡眠学 (PSG) 测量,并分为四组.
- 随机死亡率在平均随访时间11.8年内被跟踪,并使用考克斯回归模型进行分析.
主要成果:
- 与睡眠7小时或更长时间的人相比,每晚睡眠时间少于7小时的参与者具有明显更高的全因死亡风险.
- 随着睡眠时间的缩短,死亡风险增加,睡眠时间少于5小时的组具有最高风险.
- 即使调整为呼吸暂停-呼吸暂停指数 (AHI),这些关联仍然显著.
结论:
- 较短的客观睡眠时间是患有OSA的个体因任何原因死亡的独立风险因素.
- 研究结果表明,优化睡眠时间可能是改善OSA患者治疗结果的关键因素.
- 需要进一步的研究来探索睡眠延长干预措施在这个人群中的好处.
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