微观裂调节核和固态结晶倾向的无形切莱可西布的核和固态结晶倾向
Samarth D Thakore1, Kaustav Das2, Sameer V Dalvi3
1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar, Mohali, Punjab 160062, India.
Molecular pharmaceutics
|December 5, 2023
概括
无形药物中的微观裂,如塞莱科克西布,可以触发结晶,改变它们的分类. 这凸显了在药物稳定策略中考虑物理缺陷的重要性.
科学领域:
- 固态化学 固态化学
- 制药科学 制药科学
- 材料科学 是一种材料科学.
背景情况:
- 药物根据结晶倾向 (快速,中度,差) 使用热-冷-热协议进行分类.
- 无形药物稳定策略依赖于理解结晶.
- 在结晶研究中,微观样品的特征往往被忽视.
研究的目的:
- 为了研究微观裂对无形赛莱科西布结晶倾向的影响.
- 为了确定裂纹形成是否影响药物分类和稳定性.
主要方法:
- 不同扫描热量计 (DSC) 热冷热协议.
- 纳米印记用于机械性能分析.
- 核营养实验和拉曼光谱.
主要成果:
- 在冷却过程中在0-10°C之间形成的裂启动了无形赛莱科西布结晶.
- 在破裂的样本中,纳米印显示了不均的机械性能.
- 观察到裂辅助核和改变分子间相互作用的证据.
结论:
- 微观裂可以显著影响无形药物的结晶倾向.
- 裂的存在或不存在可能会改变无形赛莱科西布的分类.
- 微妙的物理事件,如微裂纹需要考虑准确的药物结晶倾向评估和稳定.
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