在南非通过家庭护理减少与艾滋病毒相关的住院后死亡率:一项随机对照试验
Christopher J Hoffmann1,2,3, Kate Shearer1,2, Boitumelo Kekana4
1Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland, USA.
概括
结构化家庭访问有望降低住院后人类免疫缺陷病毒 (HIV) 患者的死亡率. 这项试点研究提出了一个潜在的干预措施,以改善艾滋病毒患者出院后的治疗结果.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 老年学是一门学科.
背景情况:
- 人类免疫缺陷病毒 (HIV) 感染者在出院后六个月内死亡率高 (23%) .
- 需要有效的干预措施,以减少艾滋病毒感染者住院后的死亡率.
研究的目的:
- 测试这个假设,结构化的家庭访问可以减少PWH在医院出院后的全因死亡率.
- 评估住院后家庭访问干预措施的可行性和初步有效性.
主要方法:
- 南非的一项试点随机试验,将结构化家庭访问套餐 (最多6次访问) 与常规护理进行比较.
- 干预包括社会和医疗需求评估,分拣和营养支持.
- 包括没有艾滋病毒的人 (PWOH) 来告知潜在的扩大规模.
主要成果:
- 在分析的111名艾滋病毒感染者中,家庭访问组的7.3%,通常护理组的17.9%在6个月内死亡 (P = .09).
- 在家庭访问组中,死亡率下降了59%,尽管在统计学上并不显著.
- 干预组中91%的PWH接受了至少一次家庭访问.
结论:
- 医院后的家庭访问是可行的,可以提供并显示初步有效性,降低PWH的死亡率.
- 像COVID-19这样的挑战影响了招生,突出了扩大规模的适应性策略的需要.
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