拓数据分析揭示了一个核心基因表达骨干,它定义了整个开花植物的形式和功能
Sourabh Palande1, Joshua A M Kaste2,3, Miles D Roberts3
1Department of Computational Mathematics, Science & Engineering, Michigan State University, East Lansing, Michigan, United States of America.
PLoS biology
|December 5, 2023
概括
开花植物 开花植物
科学领域:
- 植物生物学 植物生物学
- 基因组学就是基因组学.
- 进化生物学是进化的生物学.
背景情况:
- 开花植物 (芽植物) 在1.25亿年前进化,并主导着陆地生态系统.
- 植物适应是由复杂的基因和通路相互作用驱动的.
- 将基因表达与身体特征 (形态) 联系起来是一个重大的生物挑战.
研究的目的:
- 开发和应用一种新的分析框架,以了解开花植物中的基因表达模式.
- 通过拓数据分析 (TDA) 将基因表达数据与植物组织和应激反应联系起来.
主要方法:
- 实施拓数据分析 (TDA) 来分析高维基因表达数据.
- 在TDA中使用镜头功能来表示植物组织类型和压力条件.
- 生成了Mapper图形,以可视化多种类型的血管种中基因表达的拓结构.
主要成果:
- TDA成功地创建了基因表达的拓表示,显示从叶子到种子的梯度以及健康到压力状态的梯度.
- 识别了血管苗中保存的基因表达模式,可以区分组织类型和应激反应.
- 与组织TDA相关的基因在光合作用,生长,发育和应激反应等核心功能中得到丰富.
结论:
- 拓数据分析 (TDA) 是解剖复杂植物基因表达数据的强大工具.
- 揭示了一种保存的"表达骨干",它是植物形式和功能的基础.
- 这种方法为植物适应和发育的遗传基础提供了新的见解.
更多相关视频
相关概念视频
Structure of a Gene
12.6K
A gene is the fundamental unit of heredity. Every individual has two copies of each gene, one inherited from each parent. Although most people contain the same genes, there is a small fraction that is slightly different amongst people. A gene with a small difference in its sequence of DNA bases forms different alleles, contributing to different phenotypes.
However, only 1% of the DNA is composed of genes that encode proteins; the rest, 99% is non-coding DNA. This non-coding DNA performs...
However, only 1% of the DNA is composed of genes that encode proteins; the rest, 99% is non-coding DNA. This non-coding DNA performs...
12.6K
Morphogenesis
28.2K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
28.2K
Regulation of Expression at Multiple Steps
917
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
917
Cell Signaling in Plants
5.6K
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
5.6K
Organization of Genes
68.6K
Overview
68.6K
Regulation of Expression Occurs at Multiple Steps
3.1K
3.1K


