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关于开发新生儿败血症核心结果集的议定书 (NESCOS)
Petek Eylul Taneri1,2, Jamie J Kirkham3, Eleanor J Molloy4,5
1HRB-Trials Methodology Research Network, University of Galway, Galway, Ireland.
PloS one
|December 5, 2023
概括
为新生儿败血症研究制定核心成果集 (COS) 将标准化结果测量. 这旨在改善治疗有效性研究,减少研究浪费,以获得更好的婴儿健康结果.
科学领域:
- 新生儿医学 新生儿医学
- 公共卫生 公共卫生
- 研究方法研究方法研究方法学
背景情况:
- 新生儿败血症是一个重大的全球卫生挑战.
- 关于新生儿败血症治疗的现有研究受到了不一致的结果测量,阻碍了有效的分析和比较.
- 在新生儿败血症研究中,需要标准化结果报告.
研究的目的:
- 开发一个以共识为导向的核心成果集 (COS) 来评估新生儿败血症治疗的有效性.
- 解决目前在新生儿败血症研究中报告的结果措施的异质性.
- 提高新生儿败血症研究结果的可比性和综合性.
主要方法:
- 对新生儿败血症结果的现有文献进行了定性系统审查.
- 补充性定性系统审查,以确定对各种利益相关者 (家长,医疗保健提供者,研究人员) 重要的结果.
- 一个实时德尔菲调查,涉及研究人员,医疗保健提供者和患者家属来优先考虑结果,随后是共识会议.
主要成果:
- 该研究正在开发新生儿败血症的COS.
- 通过系统审查和Delphi调查,正在收集利益相关者的意见.
- 协商一致会议将根据全面的利益相关者参与,最终确定COS.
结论:
- 开发的核心成果集将在新生儿败血症研究中标准化结果测量.
- 预计这种标准化将提高研究证据的质量,可比性和综合性.
- COS的目标是减少研究浪费,并最终提高新生儿败血症治疗的有效性.
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