微生物组和传染病的研究
Louis-Patrick Haraoui1,2,3, Martin J Blaser3,4,5
1Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
概括
抗生素的使用对抗生素耐药性 (AMR) 以外的健康有重大影响,通过破坏人类微生物群来促进非传染性疾病. 对抗生素使用的细微方法对于长期健康至关重要.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 抗生素通过治疗感染和使复杂的手术成为可能,彻底改变了医学.
- 抗菌素耐药性 (AMR) 是广泛使用抗生素的一个主要后果.
- 人类微生物组越来越被认为对发育和生理学至关重要.
研究的目的:
- 重新评估抗生素使用超出AMR的广泛影响.
- 突出抗生素引起的微生物组破坏与非传染性疾病之间的联系.
- 倡导对抗生素干预措施进行更全面的风险效益分析.
主要方法:
- 文献综述和新兴科学证据的综合.
- 隐喻框架 (冰山模型) 来说明抗生素效应的范围.
- 讨论生物成本和治疗策略.
主要成果:
- 抗菌药物耐药性仅代表了负面抗生素后果的"冰山顶".
- 抗生素的使用越来越多地与非传染性疾病 (肥胖,糖尿病,过敏,自身免疫疾病,癌症) 有关.
- 抗生素对微生物群的破坏会对健康产生深远的长期影响.
结论:
- 抗生素对健康的负面影响远远超出了AMR的范围,影响了多个生理系统.
- 需要一个范式的转变,在抗生素处方中考虑微生物群健康.
- 未来的战略应侧重于微生物群的保护和恢复以及感染控制.
相关概念视频
Infection
8.0K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
8.0K
Factors Affecting the Risk of Infection
11.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.8K
Defense Mechanism Against Infection
6.5K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
6.5K
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Surface Membrane Barriers
1.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K
Skin Diseases and Disorders
3.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.9K


