初级硬化性胆管炎的发病率和患病率:基于人口的研究的元分析
Jared Cooper1,2, Ante Markovinovic1, Stephanie Coward1
1Division of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.
Inflammatory bowel diseases
|December 5, 2023
概括
在一般人群中,原发性硬化性胆道炎 (PSC) 的发生率和流行率较低. 需要在亚洲,非洲和拉丁美洲进行进一步的研究,以了解全球PSC流行病学.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
- 胃肠病学 胃肠病学
背景情况:
- 初级硬化性胆道炎 (PSC) 是一种慢性肝病,患病率和死亡率很高.
- 公共医疗保险 (PSC) 显著影响医疗保健利用率.
- 了解PSC的发病率和流行率对于公共卫生至关重要.
研究的目的:
- 系统地审查和对PSC发病率和流行率的基于人口的研究进行元分析.
- 提供针对原发性硬化性胆道炎的最新全球流行病学数据.
主要方法:
- 在Medline和Embase数据库中进行系统搜索.
- 包括基于人口的研究报告PSC发病率或发病率在定义的地理区域.
- 随机效应的元分析,以计算聚合的发病率和流行率.
主要成果:
- 分析包括来自北美,亚洲,欧洲和大洋洲的14项发病率和12项流行率研究.
- PSC的发病率为每10万人/年0.87.
- 每10万人中PSC的患病率为13.53.
结论:
- 初级硬化性胆道炎在一般人群中发生率和流行率较低.
- 未来的流行病学研究应该集中在亚洲,非洲和拉丁美洲.
- 这将使全球原发性硬化性胆管炎流行病学的更全面的评估.
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