在现实生活中坚持毒药免疫疗法和上腺素自注射器
Louise Parke1, Henrik Fomsgaard Kjaer1, Olav Sivertsen Garvik2
1Department of Dermatology and Allergy Center, Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital, Odense, Denmark.
International archives of allergy and immunology
|December 5, 2023
概括
患有毒素过敏的患者对毒素免疫疗法 (VIT) 的坚持度很高,超过了吸入过敏原的SCIT. 然而,如果早期停止VIT,很少有患者获得上腺素自注射器 (AAI).
科学领域:
- 过敏和免疫学 过敏和免疫学
- 临床研究 临床研究
- 公共卫生 公共卫生
背景情况:
- 毒素免疫疗法 (VIT) 和上腺素自注射器 (AAI) 对于管理毒素过敏症至关重要.
- 关于患者遵守这些治疗方法的数据有限.
- 这项研究评估了毒素过敏患者对VIT和AAI的坚持.
研究的目的:
- 在有毒素过敏的患者中评估VIT和AAI的坚持率.
- 为了比较VIT坚持与吸入过敏原的皮下免疫疗法 (SCIT).
- 为了确定影响治疗坚持的因素.
主要方法:
- 丹麦奥登塞大学医院过敏中心 (2010-2014) 患者的回顾性分析.
- 数据来源于丹麦国家卫生服务处方数据库.
- 多变量后勤回归分析了依据过敏原类型,年龄,性别,巨细胞瘤和治疗地点的坚持.
主要成果:
- 坚持三年:VIT 92.4%与SCIT 87.4%相比.
- 5年的坚持时间:VIT 84.1%与SCIT 74.8% (p=0.045).
- 5年后,女性的VIT坚持率高于男性 (p=0.008). 在VIT提前终止后,只有28.6%的人购买了AAI.
结论:
- 在吸入过敏原的VIT和SCIT中观察到高坚持率.
- 对VIT的5年坚持明显高于SCIT.
- 在VIT停止后,低AAI采购突出了应急准备的潜在缺口.
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