通过胸部计算机断层扫描对肺移植患者的骨矿物质密度的评估
Ryobu Mori1, Tomohiro Handa1,2, Akihiro Ohsumi3
1Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Respiration; international review of thoracic diseases
|December 5, 2023
概括
肺移植接受者经历了显著的骨矿物密度损失,增加了骨质疏松症的风险. 肺移植后早期的双酸盐治疗可能会减轻这种骨损失并减少骨折发生率.
科学领域:
- 整形外科 整形外科 整形外科
- 肺部病理学 肺部病理学
- 内分泌学 在内分泌学.
背景情况:
- 肺移植 (LT) 接受者面临骨矿物密度 (BMD) 损失的高风险.
- 有限的研究已经纵向评估了LT后的BMD变化.
研究的目的:
- 为了调查LT接收者的串行BMD变化.
- 为了确定与LT前后BMD下降和压缩骨折相关的临床因素.
主要方法:
- 对128名成年LT接受者的回顾性观察研究.
- 在基线时使用计算机断层扫描 (CT) 进行串行BMD测量,在LT后的3个月和12个月.
- 评估骨质疏松症的频率和相关因素,包括压缩骨折.
主要成果:
- 与对照组相比,LT接受者显示较低的LT前BMD,COPD与LT前骨质疏松症相关.
- 在LT后12个月内,骨质疏松症的患病率从20%增加到43%.
- 低剂量葡萄糖皮质体使用在LT前与快速的骨质量损失相关;早期使用双酸盐减轻了损失和减少骨折.
结论:
- 接收LT的患者在移植后极易发生骨髓损失和骨折.
- 早期的双酸盐干预似乎有利于减少BMD损失和压缩骨折.
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