在早产婴儿中,大脑功能与微观结构大脑成熟之间的关系
Ira Winkler1, Maria Sappler1, Elke Ruth Gizewski2,3
1Department of Pediatrics II (Neonatology), Medical University of Innsbruck, Innsbruck, Austria.
Neonatology
|December 5, 2023
概括
使用振幅集成脑电图 (aEEG) 对早产婴儿的早期大脑功能监测与通过扩散张力成像 (DTI-MRI) 测量的微结构发育相关,预测神经发育结果.
科学领域:
- 新生儿神经科学 新生儿神经科学
- 神经成像是一种神经成像.
- 发育儿科 发育儿科
背景情况:
- 过早出生的婴儿面临着在术语等效年龄 (TEA) 时大脑成熟受损的风险.
- 扩散张力成像 (DTI-MRI) 量化了白质微观结构 (FA,ADC).
- 幅度集成电脑图 (aEEG) 评估电皮质活动和大脑功能.
研究的目的:
- 研究早产婴儿TEA中功能性大脑成熟 (aEEG) 和微观结构发育 (DTI-MRI) 之间的相关性.
- 评估这两种方法在24个月校正年龄时对神经发育结果的预测价值.
主要方法:
- 对446名早产婴儿 (<32周妊娠年龄) 的回顾性单中心研究.
- 计算了EEG总成熟度得分和DTI-MRI FA/ADC值之间的斯皮尔曼等级相关性.
- 使用多变量线性回归来比较EEG和DTI-MRI与神经发育结果的关联.
主要成果:
- 在TEA时发现了EEG总成熟度得分和身体质体的FA/ADC值之间的显著相关性.
- 在考虑到围产期变量后,这种相关性在早期时间点 (2日,3日) 仍然非常显著.
- EEG (第二天,第三天) 和DTI-MRI (大脑体腹) 都显示出与神经发育结果的显著相关性.
结论:
- 通过aEEG监测早期的功能性大脑成熟,可以预测早产婴儿体微观结构的发展.
- 这种早期评估显示了与后来的神经发育结果的关系,突出了早期干预的潜力.
相关概念视频
Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
Neurulation
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Neurogenesis and Regeneration of Nervous Tissue
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Neuroplasticity
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Development of the Sexual Organs in the Embryo and Fetus
Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...
Information Processing Approach
The information-processing theory of cognitive development centers on fundamental mental processes, including attention, memory, and problem-solving skills. Researchers in this field examine how cognitive abilities, such as working memory, evolve and influence children's overall development. Studies indicate that children with stronger working memory tend to excel in reading comprehension, math, and problem-solving compared to peers with less efficient memory skills. Low working memory is also...


