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婴儿肠道微生物群有助于小鼠的认知表现

Tomás Cerdó¹, Alicia Ruiz-Rodríguez², Inmaculada Acuña³

¹Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, 14004 Córdoba, Spain; Centre for Rheumatology Research, Division of Medicine, University College London, London WC1E 6JF, UK.

Cell host & microbe

|December 5, 2023

概括

婴儿的肠道微生物组合影响了6个月的认知发育. 特定的肠道细菌及其代谢物,如histidine,与更高的认知功能有关,这表明其起因作用.

科学领域:

微生物学微生物学
神经科学是一个神经科学.
代谢学代谢学代谢学

背景情况:

肠道微生物群在婴儿神经发育中起着至关重要的作用.
早期的肠道微生物组组成越来越被认为是影响认知结果的因素.

研究的目的:

建立婴儿复合认知和6个月的肠道微生物群组成之间的联系.
研究特定微生物代谢物的作用,如histidine,在婴儿的认知.

主要方法:

分析肠道微生物群的组成,多样性和婴儿的均性.
甲基蛋白质组和代谢组分析以确定微生物-代谢物-认知关联.
将便微生物群移植到无菌小鼠中,以评估认知特征的可传播性.

主要成果:

具有较高复合认知的婴儿表现出更大的肠道微生物多样性和均性.
微生物胺氨酶和婴儿胺代谢与认知有关.
便移植表明,包括记忆在内的认知特征可以通过肠道微生物群传播.
特定的细菌物种 (Phocaeicola, Bacteroides, Bifidobacterium) 和改变的histidine代谢物水平与小鼠的增强认知有关.

结论:

肠道微生物群在婴儿的认知发育中起着起因作用.
肠道微生物群对西斯蒂丁代谢物水平的调节是这种效应的潜在机制.

关键词:

认知认知认知没有细菌的小鼠.在这里,我们可以看到子子.希斯蒂丁的代谢过程婴儿婴儿婴儿婴儿婴儿婴儿婴儿形态保护学与社会主义.我们的微生物群.

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