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发现了Saccharothrix的二次代谢潜力

Bin Wei¹, Xian Luo¹, Zhen-Yi Zhou¹

¹College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.

Biotechnology advances

|December 5, 2023

概括

像Saccharothrix这样的罕见的动态菌体是新型生物活性化合物的丰富来源. 本综述探讨了138种代谢物,将它们与生物合成基因集群联系起来,并揭示了天然产品发现的未开发潜力.

科学领域:

微生物学微生物学
自然产品化学自然产品化学
生物信息学是一种生物信息学.

背景情况:

罕见的actinomycetes对于发现新的生物活性二次代谢产物至关重要.
萨卡罗特里克斯属是各种生物活性化合物的有希望的来源.
萨卡罗特里克斯的二次代谢潜力仍未得到充分研究.

研究的目的:

为了提供Saccharothrix衍生的二次代谢产品的全面概述.
将化学结构和生物活性与生物合成途径联系起来.
为了突出Saccharothrix未被充分探索的生物合成潜力.

主要方法:

对138种来自Saccharothrix的二次代谢产物进行文献综述.
根据生物合成途径对代谢物进行分类.
化学信息和生物信息分析将代谢物与生物合成基因集群 (BGCs) 连接起来.

主要成果:

138种二次代谢物的详细概述,分为五组.
对九种生物活性代谢物的实验性特征生物合成途径的探索.
在Saccharothrix中建立了代谢物家族和BGC家族之间的联系.

结论:

萨卡洛特里克斯具有显著的未开发的生物合成潜力.
该研究提供了关于Saccharothrix二次代谢产物及其BCC的全面观点.
提供了从Saccharothrix中发现新型自然产品的有针对性的指导.

关键词:

生物活性生物活性生物信息学是一种生物信息学.生物合成基因集群生物合成基因集群化学信息学化学信息学罕见的行为菌体.萨卡洛特里克斯 (Saccharothrix) 是一种糖分.二次代谢产物二次代谢产物

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