上升眼睛:欧米茄-3脂肪酸对糖尿病视网膜病变的影响
Emily L Sammons1, Georgina Buck2, Louise J Bowman1
1Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
Ophthalmology
|December 5, 2023
概括
在一项大型随机试验中,欧米茄-3脂肪酸 (FA) 在预防糖尿病视网膜病变 (DR) 进展方面没有显著的益处. 这些发现表明,每天1g的欧米茄-3脂肪酸对DR结果没有临床意义.
科学领域:
- 眼科医生 眼科 眼科
- 心脏病学 心脏病学
- 营养科学 营养科学
背景情况:
- 临床前研究表明,omega-3脂肪酸 (FA) 可能会防止糖尿病视网膜病变 (DR).
- 随机试验证据证实这些好处在人类缺乏.
- 在ASCEND试验中,研究了糖尿病患者的心血管结果.
研究的目的:
- 提供关于omega-3脂肪酸对糖尿病视网膜病变结果的影响的随机证据.
- 评估每日omega-3脂肪酸补充剂在预防DR进展方面的有效性.
- 评估omega-3脂肪酸对可转移性视网膜病变和黄斑病变的影响.
主要方法:
- 一项ASCEND试验的副研究,涉及15,480名英国成年糖尿病患者.
- 参与者每天接受1g的omega-3脂肪酸或安慰剂.
- 结果通过与国家卫生服务糖尿病眼部查计划和医疗记录审查的联系来评估结果.
主要成果:
- 对7360名参与者获得了链接数据.
- 在omega-3FA和安慰剂组 (14.8%与13.9%,速率比1.07,P=0.29) 之间,可转移疾病事件没有统计学上显著的差异.
- 对于二级或三级结局,包括视网膜病变的进展和糖尿病黄斑病,没有观察到显著差异.
结论:
- 这项大型前性研究发现,每天服用1克欧米茄-3脂肪酸对糖尿病视网膜病变没有临床意义上的益处.
- 这些发现不支持使用omega-3脂肪酸来预防或治疗DR.
- 可能需要进一步的研究来探索omega-3s在糖尿病管理中的其他潜在作用.
相关概念视频
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
01:28Diabetic Nephropathy
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
01:22Diabetic Neuropathy
DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...