![An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F66708.jpg&w=3840&q=50)
如何进行FAPI PET? 一项加快的系统审查,为使用不同FAPI标记物进行FAPI PET成像提供建议
Morten Bentestuen1, Surenth Nalliah2, Marie M K Stolberg3
1Department of Nuclear Medicine and Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Seminars in nuclear medicine
|December 5, 2023
概括
本综述总结了纤维细胞激活蛋白抑制剂 (FAPI) PET扫描程序,发现了常见的做法,但数据有限,可以进行优化. 有证据支持[68Ga]Ga-FAPI-46的早期扫描时间,有助于未来的FAPI PET研究.
科学领域:
- 核医学是一种核医学.
- 放射化学 放射化学是指辐射化学.
- 瘤成像学成像学
背景情况:
- 纤维细胞激活蛋白抑制剂 (FAPI) 阳离子发射断层扫描 (PET) 成像正在出现各种癌症.
- 标准化的FAPI PET扫描程序尚未建立,这阻碍了最佳的图像获取.
- 本综述从已发表的文献中综合了当前的FAPI PET扫描协议.
研究的目的:
- 提供文献中不同FAPI PET扫描程序的首次概述.
- 根据现有证据,讨论获得最佳FAPI PET图像的高效方法.
- 为计划FAPI PET研究的机构制定临时指南.
主要方法:
- 对PubMed,Embase,Cochrane图书馆和Web of Science数据库的加快系统审查 (2023年4月).
- 包括使用FAPI追踪器的英语同行评审队列研究.
- 排除缺乏关键扫描信息或无法恢复的物品的研究.
主要成果:
- 包括159项研究,其中[68Ga]Ga-FAPI-04 (61%) 和[68Ga]Ga-FAPI-46 (12%) 是最常见的标记物.
- 大多数研究都缺乏特定的患者准备细节;常见的施用活性为80-200 MBq,[68Ga]Ga-FAPI-04.4的范围很广.
- 60分钟的注射到扫描时间占主导地位;然而,[68Ga]Ga-FAPI-46支持更早的获取 (例如,10-30分钟) 与相当的瘤检测.
结论:
- 目前关于最佳FAPI PET扫描程序的数据有限,需要进一步研究.
- 标准实践包括80-200 MBq的[68Ga]Ga-FAPI-04/46和60分钟的扫描时间.
- 证据支持早期的FAPI PET扫描对[68Ga]Ga-FAPI-46的获取,提供了潜在的效率提升.
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