与急性细菌脑膜炎相关的医院前症状在儿童和成人之间有所不同
Nichlas Hovmand1,2, Helle Collatz Christensen3,4, Lene Fogt Lundbo5
1Center for Research & Disruption of Infectious Diseases (CREDID), Department of Infectious Diseases, Copenhagen University Hospital-Amager and Hvidovre, Kettegaard Alle 30, 2650, Hvidovre, Denmark. nichlas.hovmand@regionh.dk.
Scientific reports
|December 5, 2023
概括
社区获得的细菌性脑膜炎 (CABM) 呈现出各种症状,成人和儿童之间往往有所不同. 早期识别患者的关键症状,如发烧和精神状态的改变,对于及时干预至关重要.
科学领域:
- 紧急医疗 紧急医疗
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
背景情况:
- 社区获得的细菌性脑膜炎 (CABM) 是一种严重的医疗紧急情况.
- 了解医院前症状对于及时诊断和治疗至关重要.
- 目前关于医院前症状表现的知识需要进一步调查.
研究的目的:
- 分析CABM患者的医院前症状和管理.
- 为了确定成人和儿科患者之间症状表现的差异.
- 评估在前医院环境中经典脑膜炎三元体的频率.
主要方法:
- 追溯观察性研究.
- 分析了2016-2021年期间入院的209名CABM患者.
- 从紧急医疗服务电话通话录音中提取的症状数据.
主要成果:
- 精神状态改变 (58%) 和发烧 (57%) 是最常见的症状;部硬是罕见的 (9%).
- 儿童通常出现发烧,疲劳,皮疹和部硬.
- 成年人更频繁地表现出改变的精神状态和腿部疼痛.
- 脑膜炎症状的经典三元组是不常见的 (3%的人报告了这三种症状).
- 医院前抗生素的使用是不常见的 (总体为4%).
结论:
- 在CABM中,症状呈现在儿童和成人之间有显著的差异.
- 经典的脑膜炎三位一体在医院前阶段很少被报告.
- 对于潜在的CABM病例,建议立即对发烧或精神变化的患者进行评估.
- 增加医院前抗生素的管理是有限的,突出了早期治疗的潜在差距.
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