在肝硬化患者中评估胰腺 perfusion 的 Intravoxel 不连贯运动扩散权重成像
Ran Hu1, Guo-Fei Zeng1, Yu Fang1
1Department of Radiology, Chongqing Hospital of Traditional Chinese Medicine, No.6, Panxi 7th Road, Jiangbei District, Chongqing, 400021, People's Republic of China.
Abdominal radiology (New York)
|December 5, 2023
概括
肝硬化会减少胰腺血流,这是通过intravoxel不连贯运动 (IVIM) 扩散加权成像测量的结果. 在肝硬化患者中,胰腺 perfusion 分数 (f) 随着肝功能恶化而下降.
科学领域:
- 放射学 放射学是指放射学
- 医疗成像医学成像
- 胃肠病学 胃肠病学
背景情况:
- 肝硬化可以影响多个器官系统.
- 在肝硬化患者中,胰腺功能和输液可能会发生变化.
研究的目的:
- 为了评估胰腺输液特征,肝硬化患者与健康人群相比,使用intravoxel不连贯运动 (IVIM) 扩散加权成像 (DWI) 来评估胰腺输液特征.
- 为了将胰腺IVIM参数与肝功能严重程度相关联 (查尔德-普格分类).
主要方法:
- 在67名肝硬化患者和33名健康对照人群中,使用3.0TMRI扫描仪进行了输入素不连贯运动 (IVIM) 扩散权重成像 (DWI).
- 应用双指数模型来计算扩散系数 (ADCslow),伪扩散系数 (ADCfast) 和 perfusion 分数 (f).
- 胰腺IVIM参数在各组之间进行了比较,并与Child-Pugh分类相关联.
主要成果:
- 胰腺输液分数 (f) 在肝硬化患者中明显低于健康人群 (p=0.01).
- 在肝硬化患者中,胰腺f值随着Child-Pugh分类的增加而下降 (R=-0.49,p=0.00).
- 与B和C相比,Child-Pugh类A的胰腺f值显著更高 (p=0.02,p=0.00).
结论:
- 来自IVIM DWI的输液相关参数f值是评估肝硬化中的胰腺输液的宝贵工具.
- 在肝硬化中,胰腺血 perfusion 的降低是显而易见的,随着肝功能下降,肝功能进一步降低的趋势.
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