相关实验视频
Updated: Jul 9, 2025
10:24
Xenopus laevis as a Model to Identify Translation Impairment
Published on: September 27, 2015
10.8K
女性老龄化:当翻译模型无法翻译时
Gabrielle Gilmer1,2,3,4, Zachary R Hettinger1,2,5,6, Yetsa Tuakli-Wosornu7,8
1Discovery Center for Musculoskeletal Recovery, Schoen Adams Research Institute at Spaulding Rehabilitation, Boston, MA, USA.
Nature aging
|December 5, 2023
概括
老龄化研究模型往往排除了女性特有的生殖变化,如更年期,导致对女性年龄相关疾病的理解不佳. 纳入这些因素对于推进衰老生物学至关重要.
科学领域:
- 老年学是指老年学的学科.
- 生殖生物学 生殖生物学
- 临床前研究模型 临床前研究模型
背景情况:
- 与男性相比,女性患者在与衰老相关的病理中表现出更高的发病率和不良治疗事件.
- 目前的临床前老龄化模型不充分代表女性老龄化轨迹,特别是生殖衰老.
- 不到1%的衰老生物学研究包括更年期的表型,尽管生殖衰老影响了70%以上的与年龄相关的疾病.
研究的目的:
- 总结关于女性生物学常用的临床前衰老模型的局限性.
- 为将更年期,怀孕和性别考虑纳入衰老研究提供建议.
- 为研究人员,期刊,资助机构和动物供应商概述可行的步骤,以解决这些差距.
主要方法:
- 对当前临床前衰老模型的文献综述和分析.
- 确定老龄化研究中关于女性生殖生理学的关键遗漏.
- 制定建议和行动项目,以改善老龄化研究中的性别包容性.
主要成果:
- 普遍存在的衰老模型未能纳入女性衰老的关键方面,例如更年期过渡和怀孕,分娩和母乳养的影响.
- 这种遗漏导致了对了解女性年龄相关疾病的重大知识差距.
- 现有的研究主要利用不反映女性衰老生物现实的模型.
结论:
- 有必要加强临床前衰老模型,以准确反映女性衰老轨迹,包括生殖因素.
- 实施将性别因素纳入考虑的建议对于推进衰老生物学和改善妇女健康结果至关重要.
- 需要涉及研究人员,机构和资助机构的协作努力,以解决女性老龄化表型在研究中的不足.
更多相关视频
06:49Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
Published on: February 12, 2018
10.9K
05:32Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
Published on: August 11, 2023
1.8K
相关概念视频
01:26Aging
56
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
56
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:28Menopause
171
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
171
02:07Oogenesis
63.7K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.7K
01:31Translation
14.9K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
Translation Produces the Building Blocks of Life
Proteins are...
14.9K
02:07Improving Translational Accuracy
11.1K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
11.1K