在接受腹腔透析的患者中,肠道微生物组与认知障碍之间的相关性
Jingjing Wang1, Siyang Wu1, Jin Zhang1
1Department of Nephropathy, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, Anhui, PR China.
BMC nephrology
|December 5, 2023
概括
肠道微生物组的改变与腹腔透析 (PD) 患者的认知障碍有关. 分析肠道细菌,如乳杆菌和Prevotellaceae可能有助于早期诊断PD相关的认知衰退.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 神经科学是一个神经科学.
背景情况:
- 经过腹腔透析 (PD) 的患者表现出比非透析的末期病 (ESRD) 患者更高的认知障碍率.
- 驱动PD相关认知障碍的机制尚未完全理解.
研究的目的:
- 调查肠道微生物组变化的作用在PD相关认知障碍中的作用.
- 确定这些微生物组变化的预测意义.
主要方法:
- 使用16S rRNA测序对28名PD患者和29名非透析ESRD患者的肠道微生物组合进行比较.
- 使用迷你精神状态检查 (MMSE) 和蒙特利尔认知评估 (MoCA) 成绩评估认知功能.
- 分析了便样本,以确定微生物数量和结构的差异.
主要成果:
- 在PD患者和非透析ESRD患者之间观察到肠道微生物组结构和丰度的显著差异.
- 在患有认知障碍 (PCI) 和正常认知 (PNCI) 的PD患者之间,Prevotellaceae和Lactobacillus分别显示出最显著的结构和丰度差异.
- 微生物群的变化与认知功能和血清标志物相关;基于特定细菌的模型可以高精度地区分认知障碍组 (AUC高达0.848).
结论:
- 肠道微生物组分析揭示了PD患有认知障碍的患者的明显模式.
- 识别特定的细菌家族和属可以帮助早期诊断PD患者的认知障碍.
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