对药物的初始态度预测精神分裂症第一发病患者的药物坚持:在中国进行的一年前性研究
Nan Dai1, Bingjie Huang2, Tianqi Gao2
1Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan, China.
BMC psychiatry
|December 5, 2023
概括
患者对抗精神病药物的态度是治疗坚持的关键预测因素. 一个积极的基线态度和女性性别独立地防止在一年内停止治疗.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床心理学 临床心理学
背景情况:
- 患者对药物的态度预测了对抗精神病治疗的坚持.
- 之前的研究主要使用横截面设计,限制了对随时间推移的态度-坚持动态的理解.
- 纵向调查对于了解药物态度如何影响抗精神病治疗的坚持和停药至关重要.
研究的目的:
- 为了研究药物态度和坚持抗精神病治疗的一年之间的纵向关联.
- 在治疗期间不同时间点确定与药物态度相关的因素.
- 为了确定药物态度对治疗中止的预测价值.
主要方法:
- 在52周的七个时间点收集了人口统计,精神病理,社会功能和药物态度 (药物态度库存,DAI-10) 的数据.
- 使用曼-惠特尼U测试来评估DAI-10分数与坚持之间的关联.
- 雇佣的接收器运行特征 (ROC) 分析以确定最佳的DAI-10切断点和Cox回归以分析停产预测因素.
主要成果:
- 在完成和停止治疗的患者之间,基线DAI-10得分显著不同 (p=0.004).
- 女性性别和基线DAI-10得分> -1是独立的保护因素,防止停止抗精神病治疗.
- 基线疾病严重程度 (CGI-s) 和洞察力与DAI-10分数相关.
结论:
- 患者在基线对抗精神病药物的态度是停止治疗的关键预测因素.
- 积极的基线态度和女性性别与持续的抗精神病治疗坚持相关.
- 在治疗早期了解和解决患者的药物态度可能会改善长期的药物坚持.
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