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Updated: Jul 9, 2025

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高效的基因组编辑通过CRISPR-Cas9核糖蛋白 (RNP) 传递到介质干细胞中

A Reum Han1, Ha Rim Shin2, Jiyeon Kwon3

  • 1Department of Translational Medicine and Department of Biochemistry and Molecular Biology, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505; Stem Cell Immunomodulation Research Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

BMB reports
|December 6, 2023
PubMed
概括

与等离子体DNA相比,核蛋白 (RNP) 复合体在介质干细胞 (MSC) 中提供了优越的基因组工程. 这种优化的CRISPR-Cas9 RNP方法通过提高编辑效率和减少细胞毒性来增强MSC的治疗潜力.

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相关概念视频

CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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